According to the World Health Organisation the incidences of cancer are increasing as the global population grows. One in three people in will be affected by cancer throughout their lifetime, while 90% of cancer that reoccurs within six months is resistant to chemotherapy.

The endoplasmic reticulum (ER) is a structure within cells that is responsible for multiple functions, including serving as a sensor of cellular stress. Persistent ER stress has a significant impact in several diseases including cancer and neurodegenerative disease, as well as autoimmune conditions. Extensive research by our academic founders and others has defined a role of the unfolded protein response (UPR) pathway, a major constituent of ER stress, in the survival of tumour cells seen in incidences of chemotherapy resistance.

Cell Stress Discoveries Ltd. was founded with the goal of developing therapeutic candidate molecules that will switch off this tumour survival mechanism.